Co-Crystal Polymorphs
Are you wondering why crystal quality varies batch-to-batch?
The crystallization route can influence the morphology, crystal size distribution, purity and polymorphic fraction of the final product. These differences in crystal quality can have an effect on handling or filterability. The Crystalline® PV makes it is possible to see if polymorphic forms with different crystal shapes and particles size distributions are formed during the crystallization process. It is important to be aware of solid state conversions during the production of crystalline materials, in order to ensure batch-to-batch consistency in the materials produced. The Crystalline® PV requires relatively small amounts of sample (working volume 1-6 mL), making it possible to do these studies already in an early stage of development.
Download Case study Co-crystal polymorphs of Carbamazepine-Isonicotinamide
Watch the formation of different polymorphs
In this case study 2 polymorphic forms of 1:1 co-crystals of Carbamazipine:Isonicotinamide were observed during the crystallization process. The final products were of the same stable form, but the different crystallization routes had an effect on the final purity, particle size distribution and shape.
Movie experiment 1:
The stable form I is formed during the cooling crystallization of Carbamazipine:Isonicotinamide.
Movie experiment 2:
During the subsequent cooling cycle, the less stable, needle shaped, form II is formed first, before transforming to the plate like form I.