Crystal16

	Solubility curves within 4 hours using only 100 mg!
	16 crystallization parallel experiments, in small volumes with online turbidity measurement!
	16 parallel screens for co-crystals, polymorphs, anti-solvents in volumes 0.5-2mL!

The Crystal16® parallel crystallizer is a multiple reactor station developed by Avantium providing a solution to an unmet need in solid-state research and process development.

The system is a user-friendly system with uncomplicated software that enables you to accelerate your crystallization research.

The top 20 pharmaceutical companies use multiple units of our Crystal16® within their crystallization departments. This tool will help you build up your laboratory capabilities with easy-to-use high performance system for the applications.

Applications

Over the years our customers have been able to apply the technology to a wide range of other applications within the crystallization R&D, of which one is the tedious work of isolating the "single crystal", needed for structural identification of a compound.

More pharmaceutical applications:

Co-Crystal screening
Chiral separation
Anti-solvent determination
Salt screening
Polymorph screening
Polymer dissolution studies (LCST and UCST)

Technical Info

The Crystal16® multiple-reactor system can hold 16 (4 x 4) standard HPLC glass vials (11.5 mm diameter, flat bottomed, 1.8 mL volume).

A unit consists of four independently heated aluminum reactor blocks encased in a robust bench top setup taking a minimum of your valuable lab space. These blocks are electrically heated and cooled by a combination of Peltier elements and a cryostat.

In order to prevent condensation of water on the reactor blocks and electronics during runs at temperatures below 10°C the Crystal16® system provides an inlet for a dry purge gas (typically nitrogen).

Operating Parameters

Temperature range: -15°C to 100°C
Heating/cooling:
Individually programmable per reactor block
Temperature profile:
Programmable with up to 25 heating/cooling/hold steps per run
Temperature control accuracy: 0.1°C
Heating/cooling ramps: Programmable between 0°C and 20°C/min
Stirrer speed (magnetic stirrer bars):
Programmable from 0 - 1250 rpm
Turbidity measurement:
Per individual reactor in transmission

CrystalClear

CrystalClear is a software package that helps Crystal16® users to transform "data produced" by the Crystal16® into "valuable information" in a few simple steps.

Step 1: Import your project data files from Crystal16® into CrystalClear

Step 2: Visualize and (optionally) edit Clear and Cloud points to one's need

Step 3: Visualize the Meta Stable Zone Width; valuable information as a foundation of a solid crystallization process

Step 4: Automatically create a final report exportable to Word