Journals
Below is an overview of articles featuring Crystal16®. Click on the links below to see all the articles.
A selection
Combination of a Single Primary Nucleation Event and Secondary Nucleation in Crystallization Processes
The summary below is written by Somnath S. Kadam, on of the authors of the article. The article was published in the journal Crystal Growth & Design in March 2011.
Nucleation is a commonly encountered phenomenon during industrial crystallization but our understanding about it is surprisingly poor. The common perception is that millions of nuclei are formed in a clear solution rapidly if this solution is sufficiently supersaturated. However, we have recently identified a completely different nucleation mechanism: the single nucleus mechanism. This new theory could be formulated on the basis of careful optical observations of the nucleation process at different scales and an analysis of the stochastic nature of the nucleation process. Read more
Pfizer developed a new Medium-throughput method for screening Hydrates
Researchers at Pfizer developed a new method for screening hydrates. One can discover the propensity of a drug to form hydrates, using as little as 15-20 mg of sample, within 6 hours. Thanks to the small amount of sample which is needed, this method has applicability in early stages of drug development - allowing for adequate precautions to be taken during process development and even selection of compounds. Read more about this new method
Understand the solid state behavior of chiral compounds
In a new publication from the Delft University of Technology in The Netherlands, in Crystal Growth and Design, researchers describe a new screening method to measure the phase diagrams of chiral compounds. The understanding of the solid state behavior of chiral compounds makes it possible to design chiral separation processes making use of crystallization. Read more about this publication and download the poster