Did you read the article in the American Pharmaceutical Review on Crystallization by Johnson & Johnson?

It describes the use of small scale (1 mL) experiments for solubility studies. In this article the Crystal16 is featured in a few experimental approaches towards scalable crystallization processes.

Case studies are presented on:

• Solubility in Function of time
• Crystallization of an amorphous product
• Causes of low crystalline products?
• Crystallization vs. slurry conversion

The Crystal16 from Avantium is the only commercially available bench top system which can operate on a 1mL scale. In the article the operating principles of the Crystal16 are described and illustrated in Figure 1.

A comparison between 1 L and 1 mL experiments is shown in Figure 3, illustrating the scalability of solubility information, obtained from a Crystal16.

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