Case study: Real Time Monitoring of Crystal Habit Changes during a Slurry Conversion

It is of crucial importance to the pharmaceutical industry to control the polymorphic crystallization and formation of solvates. Often polymorphic transformation or hydration can be observed empirically through monitoring habit changes of crystals.

What is this case study about?

The need to study and control these transformations has led to the development of a small scale parallel crystallizer with particle visualization capabilities in combination with programmable temperature control and transmission analytics.

This case study illustrates the use of visual information and particle size statistics, on a millilitre scale, to monitor transformation processes which are accompanied by changes in crystal habit.