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Co-crystal Screening

With an increase in the size and complexity of the molecules that enter into drug development, companies face a larger number of compounds that are either poorly soluble, difficult to crystallize or problematic with respect to desired physical chemical properties for successful development.

Traditional approaches such as salt formation may no longer offer sufficient opportunities to provide a solution and new strategies are actively being explored. Co-crystals have been identified as an interesting option. Co-crystals provide new opportunities to increase the dissolution rate, improve physical chemical properties of the API or to crystallize compounds that fail to crystallize by applying more conventional approaches.

The ability of an API to form a co-crystal is dependent on a range of variables, including the types of co-former, the API co-former ratio, the solvents, the temperature, the pressure, the crystallization technique, etc. By systematically exploring the combination of relevant variables Avantium increases the chance of discovering a co-crystal with the desired properties. Avantium has built a successful track record in identifying and characterizing co-crystals by applying a unique combination of in-depth crystallization expertise, rational design of experiments and proprietary high-throughput technologies for experimentation and analysis.