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    • Amorphous Solid Dispersion Screening
    • Enantiomer Resolution Screening
    • Crystallization Process Optimization
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Salt Screening

The physicochemical properties of drug substances can be altered significantly by salt formation. Although salt formation is most often employed to modify aqueous solubility, other properties are also influenced. Avantium's technology platform for crystallization screening accommodates salt screening studies using only minimal amounts of drug substance while still performing a large number of experiments. High-throughput salt screening is used for both early-phase salt selection studies and broad patent protection. The key in salt screening is not to form the salt as such, but to crystallize the compound and determine the conditions under which the salt with the correct properties is crystallized.

Solvents for the screen are selected using Avantium's rational design tool that enables researchers to select a minimal set of solvents while still covering the diversity of physical properties present in the solvent database.

Crystallization experiments are performed in well plates containing 96 individually sealed wells of 40 µl and at mL scale. After crystallization and filtration the solid samples are immediately characterized using high-throughput X-ray powder diffraction as the primary analytical technique.

Sophisticated software classifies the high-quality XRPD patterns and forms are assigned by a solid state expert. Further characterization using thermal analysis, HT microscopy imaging, Raman spectroscopy, single crystal X-ray diffraction and Dynamic Vapor Sorption can be performed. On basis of this data the solid forms are ranked in order of stability, crystallinity, etc.